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Moreover, a variable amount of inflammatory cells, presumably macrophages, inside and around the tumor equally express iNOS (Klotz et al., 1998; Aaltoma et al., 2001). In contrast to prostate cancer, normal putatively undiseased prostatic tissue as well as tissue from benign prostatic hyperplasia stain negative or only weakly positive for iNOS (Klotz et al., 1998; Gradini et al., 1999; Aaltoma et al., 2001; Baltaci et al., 2001). Although strong iNOS expression has been correlated to a rapid cancer cell proliferation rate, dedifferentiation and prediction of poor survival (Aaltoma et al., 2001), the role of iNOS activity in prostate cancer remains unclear.Prostate cancer is the second most common cause of tumor associated death in men in the United States and accounts for 9% of all cancer related deaths among men in the European Union. Bitter gourd weight loss An initial marker that showed some promise was stem cell antigen 1 or Sca1. Sca1+ cells were shown to be a subpopulation of the label retaining epithelial cells, and when isolated they showed a degree of in vivo reconstitution ability. However, subsequent studies would identify markers which could enrich for MaSCs to a much higher degree of purity, and MaSCs identified by other methods have been shown to be Sca1low/ 7, 16..

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