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Interestingly, prenatal folic acid supplementation is a protective factor for both neural tube defects and ASD. Folate and folic acids are major environmental contributors to DNA methylation and are protective factors for a number of human diseases, but the epigenomics of protection is poorly understood. Studies have shown that mothers of children with autism were significantly less likely to take a prenatal supplement around conception and reported significantly lower average intake of folic acid than mothers of typically developing children during the first pregnancy month.62, 63, 64 Further, if mothers did not report taking prenatal supplements periconceptionally and they or their child had the susceptible MTHFR allele, their child was at much higher risk for autism.62 As supplemental folic acid demonstrates antioxidant properties65 and rectifies conditions of oxidative stress and low methylation capacity66, 67 potentially induced by environmental toxins, the reduced risk associated with periconceptional prenatal vitamin use could be a result of mechanisms that combat the effects of environmental toxins by providing important methyl donors for DNA methylation.. Why Holley Mangold is weightliftings rock star In the Swedish school system, all the pupils follow the same core curriculum until grade 9. The pupils were followed up again at ages 18, 21 and 30 years using the same survey questionnaire. Extensive work was carried out to reduce the nonresponse rate to a minimum.
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