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The above studies,6,7,8,9,10,11,12 as well as other reports,13,14 indicated that a reduced absolute sympathetic activity or a blunted sympathetic reactivity in certain physiological conditions was found in adult obese subjects. Additionally, in the pediatric obesity research field, our current study15 demonstrated that the obese children possess reduced SNS activity, as shown in adult obese subjects, and such autonomic depression is associated with the duration of obesity. These data strongly support the hypothesis that a low level of SNS activity leads to the onset or the development of obesity. meizitang botanical SKOV3ip1, HeyA8 or Tyk nu cells were cultured on plastic and treated with the compounds at concentrations of 1, 5 or 10M, and cell viability was measured after 16h. Five of the 6 compounds (alexidine dihydrochloride, beta escin, cantharidin, prochlorperazine dimaleate and tomatine) had no effect on viability at 16h (EC50>10M). Next, the effect of these five compounds on cell viability after 72h of treatment was evaluated with the intention of prioritizing compounds that also inhibit OvCa viability after long term treatment (Supplementary Fig.