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13 the vast majority of abnormal torso application submissions What is Fibromyalgia and How Do I Remedy It Received 19 September 2001; Revised 17 December 2001; Accepted 7 January 2002Top of pageAbstractMaterials and methods Results Discussion References Acknowledgements Figures and TablesThe relevance of circadian rhythms in irinotecan and oxaliplatin tolerability was investigated with regard to antitumour activity. When both drugs were given near their respective circadian times. Gastrointestinal and haematologic toxicities are dose limiting for both agents, while irinotecan can also cause asthenia and oxaliplatin can produce peripheral sensory neuropathy.Experiments in mice have indicated that the tolerability and the efficacy of both agents varied significantly as a function of drug dosing time, as a result of the rhythms which modulate cell metabolism and proliferation along the 24 time scale (L 1997).