However, in the case of the hallux, the ancestral topology of musculature in tetanuran dinosaurs is inferred to have been similar to the topology found in modern birds36,37. If so, some additional factor must have been required for torsion of Mt1. Perhaps, delayed differentiation of Mt1 led to increased plasticity, allowing embryonic musculature to significantly alter its shape. , Teenagers in binge drinking orgy The 1,536 well format also permits a quantitative HTS approach that uses an automated, robotic system to screen the large collection of compounds in a 4 point dose response23. This reduces the number of false positive hits and enables the identification of compounds that are less potent, but are still potentially relevant24.Figure 2: The primary 3D organotypic HTS in 384 well and 1,536 well formats.(a) HTS assay (384 well). The Prestwick Chemical Library of compounds at a final concentration of 10M (n=2 experiments, 1,140 compounds) was added to the 384 well 3D HTS assay.
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