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The MYC oncogene is involved in many types of human cancer. The discovery of a consistent balanced chromosomal translocation involving the MYC gene in Burkitt lymphoma was the first evidence to characterize MYC as a human oncogene.1 Subsequently, MYC gene alterations have been discovered in B cell neoplasms other than Burkitt lymphoma.2 Among those neoplasms, diffuse large B cell lymphoma is the most widely studied. The presence of MYC rearrangements in patients with diffuse large B cell lymphoma treated with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone (R CHOP) has been shown to be associated with poor prognosis.3, 4 In particular, the so called lymphomas that are characterized by MYC rearrangement and a concurrent rearrangement of other B cell lymphoma associated genes such as BCL2 or BCL6 are associated with poor response to therapy, aggressive clinical course and dismal prognosis.5, 6, 7 These lymphomas are classified as lymphoma, unclassifiable with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma in the current 2008 WHO classification of hematopoietic neoplasms.8. How to Design a Split Routine for Bodybuilding What he or she wants to do is more important. Your consent is no doubt has its own place in the life of your kid but try to make it a mutual one. Promote their desires and behave like a friend and a helping hand in the accomplishment of their desires..
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