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Whereas motor endplates in the control fetus showed increased tyrosine kinase activity (Figure 3j and k), the small AChR clusters in the FADS patient did not accumulate phosphotyrosines (Figure 3h and i). Thus, histological examination was consistent with a defect in the MUSK signaling pathway.To corroborate the above findings in fetal muscle tissue, we next investigated the AChR clustering activity of mutant and wild type MUSK in a direct comparison. Wild type and mutant MUSK were expressed in HEK293 cells with similar molecular mass (Figure 4c), migrating in SDS PAGE as a 110 kDa protein consistent with previous studies.16, 17 In myocytes derived from a fetus homozygous for the c.1724T variant, overexpression of wild type MUSK significantly increased the density of agrin induced AChR clusters (P n whereas mutant MUSKI575T did not (P n see Figure 4a and b). sureslim softgel reviews Of course, you have to find your motivation before you can embark on a winter training programme. Remind yourself that it is important that you do more year round for your general health and wellbeing, and that the core work for swimsuit season should, in actual fact, start in the preceding season for maximum impact. You need not follow your usual, strenuous summer routine in winter, only a slightly pared down version of it.