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Received 11 August 2014; Revised 29 October 2014; Accepted 10 November 2014Advance online publication 24 December 2014Top of pageAbstractFetal akinesia deformation sequence (FADS) refers to a clinically and genetically heterogeneous group of disorders with congenital malformations related to impaired fetal movement. FADS can result from mutations in CHRNG, CHRNA1, CHRND, DOK7 and RAPSN; however, these genes only account for a minority of cases. Here we identify MUSK as a novel cause of lethal FADS. meiztiang diet pill softgel A network model highlighting the functional connectivity difference between TDC and EOS subjects is shown in Figure 4A and the corresponding statistical comparisons are displayed in Figure 4B. A linear model was used to examine the differences in inter FC between TDC and EOS subjects, where age (centered to mean) and gender (coded as a factor) were included as covariates. The results showed higher inter FC in TDC than in EOS subjects in connections between the PCU and the r AG (connection 1 in Figure 4A, t(46) = 2.35, p = 0.01) and between the PCU and the l AG (connection 2 in Figure 4A, t(46) = 2.07, p = 0.02).