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Thirty nine percent of cases were discrepant. The findings indicate that a significant number of diffuse large B cell lymphomas are inherently difficult to score due to staining heterogeneity. The effect of heterogeneity can be under represented when concordance is measured among few pathologists scoring tissue microarrays. daidailua Measurements: Youth sports participation data (participation in sport club training and competitions) were assessed in 1980 and 1983 using a self report questionnaire completed in connection with a medical examination. Participants were divided into athletes and non athletes at each measurement point, and then classified into four groups: Persistent athlete, Starter, Leaver and Non athlete. A mean score of youth sport was assessed by calculating the average of four consecutive measurements (1980 MetS risk in 2001 was defined as a categorical variable based on the guidelines of the European Group for the Study of Insulin Resistance (EGIR) and as a continuous MetS score variable by summing the z scores of individual metabolic variables..