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Unfortunately, after an initial response to androgen deprivation therapy, prostate cancer growth usually recurs in a form that is resistant to further anti androgen treatment, and many men die of hormone refractory, that is, androgen independent prostate cancer (Feldman and Feldman, 2001; Cronauer et al., 2003).Androgens act via binding to the androgen receptor (AR), a ligand dependent transcription factor of the nuclear steroid hormone receptor superfamily containing two cys4 type zinc fingers. These zinc fingers enable the AR to specifically recognize androgen responsive elements (AREs), that is, palindromic DNA sequences in the promoters of androgen responsive genes such as probasin or prostate specific antigen (PSA). In the absence of androgens, the AR resides mainly in the cytoplasm in an inactive form associated with heat shock proteins. Son of a Kearney couple seeks treatment They are known to have committed and are currently under investigation for the most serious criminal offences.”It was clear Mr Smith and the gang were committing alcohol, drugs and lotteries offences at the headquarters.That was confirmed during raids in November and December, which will result in a court case next month involving alcohol and gaming charges. Detective Sergeant Turley said: “Organised crime, until late, has been investigated piecemeal. It has evolved at such speed it has caught us by surprise.”)Functions at the headquarters, especially “dance and rave” parties, were an outlet for the sale of illegal substances, the detective said.”Although the sale of alcohol is profitable at such functions, the sale of Ecstasy and methamphetamine is the major source of income.”Detective Sergeant Turley said “outlaw motorcycle gangs” were recognised internationally as major players in drug distribution and other offending.Legitimate businesses were often purchased as an effective cover for drug and extortion work.
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