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(e) Cannabinoid (CB) receptor inhibitors: Stimulation of central CB1 receptors increases appetite and fat deposition. Clinical trials of rimonabant, a selective endocannabinoid (CB1 receptor) antagonist, indicated beneficial effects on weight, waist circumference, serum lipids, C reactive protein and glycemic control in adult patients with type 2 diabetes.128, 129 The major adverse effects of rimonabant included nausea, anxiety and depression.130 The FDA did not approve rimonabant in 2007 because of concerns about neuropsychiatric adverse effects, particularly an increase in suicidality. Approved as a weight loss medication in Europe in 2006, rimonabant was withdrawn by the European Medicines Agency in 2009 because of an increase in psychiatric adverse effects.131 Clinical development of rimonabant as well as other centrally acting CB1 inhibitors such as taranabant and otenabant was suspended as a result of this adverse event profile.73, 132, 133 More recent findings on CB1 receptor antagonism in the liver, adipocytes, muscle and pancreas have raised hopes for potentially new generation of peripherally acting CB1 receptor inhibitors for treatment of obesity and its comorbid conditions such as fatty liver, insulin resistance and dyslipidemia.134, 135, 136, 137. Mother says faith helping her through shooting of son I tried making this cake for the first time and couldn get all three layers out of the pans. I used Calphalon baking pans and greased heavily. I ended up not having any desert for my family after they were so much anticipating it, I was so disappointed.