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In our first study, we saw that other polar, small molecule solvent species could also induce the cytodifferentiation and growth arrest of MELC and that simple amides were in fact somewhat more potent than DMSO22. Many such polar species were examined, but none showed potency more than threefold or so greater than that of DMSO, so it was time for a new idea. Because the potency reflects the strength of binding of a drug to its receptor, it was decided to link two amide groups to take advantage of the well known chelate effect that could lead to strong binding if there were two or more receptor sites for the amide species near each other. ball sports club you’ll probably have one soon