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Of course you need a helmet that “fits”. Make it snug, not loose. Your hair is going to get trashed. Taken together, the results strongly support a causal role of this founder mutation in MUSK, further expanding the gene set associated with FADS and offering new opportunities for prenatal genetic testing.Top of pageIntroductionFetal akinesia deformation sequence (FADS; MIM 208150) represents a group of disorders characterized by decreased or absent fetal movements. Affected infants may die in utero or shortly after birth due to severe pulmonary hypoplasia. FADS was first recognized in 1974 by Pena and Shokeir, and therefore was originally called the Pena syndrome.1, 2 The etiology of FADS is heterogeneous, including neuromuscular disorders, metabolic diseases, syndromic and environmental causes.3 Mutations in genes expressed at the neuromuscular junction (NMJ) are increasingly recognized as important causes of FADS, including CHRNA1 (MIM 100690), CHRND (MIM 100720), CHRNG (MIM 100730), DOK7 (MIM 610285) and RAPSN (MIM 601592).3 These genes however explain a minority of cases: in a cohort of 59 kindreds with Lethal Multiple Pterygium Syndrome (LMPS 253290 and FADS, it was estimated that 24 were positive for mutations in either of these genes.4Here we describe a novel founder mutation in MUSK, encoding a muscle specific tyrosine kinase essential for NMJ development5 as a frequent cause of lethal FADS in a Dutch genetic isolate. lida tablets where to buy Also, who are these drunk driving enthusiasts who all found one another? I can understand why gun owners would be angry for the same reasons about the regulation of their weapons, or why marijuana advocates would be irate (well, as irate as they can be) about the criminalization of their favorite leisure activity, because shooting guns and smoking weed are, in themselves, enjoyable. But anyone who likes drunk driving enough to stand up for it against federal law is already starting from such a misguided and soulless place that no one will ever feel sorry for them when they bemoan their mistreatment by the law. Why not take up drunk model building instead?.