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Evaluation for MYC alterations in diffuse large B cell lymphoma is typically performed by fluorescence in situ hybridization (FISH). FISH is capable of detecting MYC gene alterations that result from translocation or amplification of the gene. These genetic alterations result in MYC protein overexpression, which is ultimately responsible for the oncogenic effect.1, 2 MYC protein overexpression has also been found to occur as a consequence of other genomic events not detected by FISH.9 Thus FISH might miss a subset of diffuse large B cell lymphoma cases that demonstrate MYC protein overexpression.. Top Five MP3 Players for Running 2016 sports club and so we have a secret weapon that we’re rolling out
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