The performance of the HTS assay was very reproducible on different days and with primary cells from different patients (Supplementary Fig. 3a,b). Most importantly, known inhibitors of OvCa adhesion and invasion (for example, integrin antibodies and arginine glycine aspartic acid peptides) blocked adhesion/invasion in the 3D culture (Supplementary Fig. # Start your own food business on the cheap The reason the advertisement is significant is because it marked the first time that any toy company had attempted to peddle merchandise on television outside of the Christmas season. Until 1955, ad budgets at toy companies were minuscule, so the only time they could afford to hawk their wares on TV was during Christmas. But then came Mattel and the Thunder Burp, which, according to Howard Chudacoff, a cultural historian at Brown University, was a kind of historical watershed.
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