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Top of pageThe neuromuscular system in infectionsThe skeletal muscles, which constitute approximately 45% of bodyweight, are the major source of amino acids,14 but the heart muscle also contributes (Figure 1).18, 19, 20 Thus, a decrease in the protein content of the skeletal muscles, as well as in that of the heart muscle, is a general feature in acute infectious diseases, the magnitude of which is related to the magnitude and duration of the systemic acute phase reaction of the host. In acute myocarditis, this wasting of myocardial muscle protein occurs in parallel with the microorganism and inflammation related damage to the heart. This cytokine triggered muscle protein loss is gradually replenished when the infection has resolved.. two day diet japan lingzhi Irinotecan and oxaliplatin doses were selected on the basis of preliminary experiments in this model at our laboratory (D’Attino et al, unpublished results).Animals and synchronisationAll experiments were carried out in accordance with the guidelines approved by the UKCCCR.Male B6D2F1 mice, 6 to 7 weeks of age, were purchased from IFFA Credo (L’Arbesle, France). They were housed two per cage with water and food ad libitum, and allocated to one of the several treatment groups planned for each experiment. Cages from each group were placed on a different shelf of an autonomous chronobiological animal facility (ESI Flufrance, Arcueil, France).